Microflora in Human and Animals
نویسنده
چکیده
In order to investigate lhe antitunor aa1ivi1t of inteslinal nicroflora, the consrituûon of nonnalJlorav,as tested in hunan, guinea pig and uice. It u'c:s clari,fied that Eubacteriwn, Bif dobacteriunt and Bacteriodes u'ere the predominant bacterial genera in huntans. In additiott, neither Clostridium nor Enlerobacteriaceae v,as delected in guinea pigs and neither Clostridiun nor Bifdobacteriwn v,as Present in nice. Total bacterial count itr tunor-bearing uice v,ere reduced in conparison u,ith those in nornal nice. Especially, in the ileum oflwnor-bearing nice, the incidenae ofanaerobic bacterial generav,as sçikingb,decrea,sed. Frou the bacterialfound,fifq, nine (59) Iiving and killed strains isolated front intestinal nicroflora were e.raninedfor their anlitunnr activity against Ehrlich ascites tunrcr. II',vas observ'ed that I1 of the tested strains had antitunor activiS-. Four of these had rcici4,to the host, and especially, all nice injecred v'ilh PseudontoruLs aerugittosa (TYM-8), died u,ithin several days. Eubacleriuttt lentum (TYH-t l), Propionibacreriun acnes (TYM-28), Proreus nirabilis (TYM-7) and Serratia,,mrcescens (Ty-142), in u,hich antitunnr actiuir;'N,as recogniTed in living andforrnaline-killed bacleria, cured the lutnorbearing nice. The supernatant culture ofserratia narcescens contained altparenl a,1ûIu,tror activiry
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تاریخ انتشار 2014